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Aug 21, 2012 by APRIL McCARTHY
Toxic By-products of Processed Foods Lead To Abdominal Fat and Diabetes

A by-product produced when food is cooked with dry heat, a process used in more the preparation of more than 80% of process foods, has been found to lower the body’s protective mechanisms that control inflammation leading to
insulin resistance and increased body fat.

Processed foods are full of tens of thousands of preservatives and toxins, many which can cause a myriad of health issues. One of the biggest problems lies in their preparation.

Previous research has show that acrylamide is a chemical that naturally forms in certain foods, particularly plant-based foods that are rich in carbohydrates and low in protein, during processing or cooking at high temperatures.

It was first confirmed that acrylamide caused cancer in 2002 by the Swedish National Food Authority, however many have long suspected that heating any foods to high temperatures can pose problems to long-term health.

Researchers at Mount Sinai School of Medicine have now identified another common compound in food processing which may be partially responsible for the exponential increase in obesity and diabetes in the last few decades. The findings are published in the August 20, 2012 issue of the Proceedings of the National Academy of Sciences.

The research team, led by Helen Vlassara, MD, Professor and Director of the Division of Experimental Diabetes and Aging, found that mice with sustained exposure to the compound, methyl-glyoxal (MG), developed significant abdominal weight gain, early insulin resistance, and type 2 diabetes. MG is a type of advanced glycation endproduct (AGEs), which is produced when food is cooked with dry heat which ultimately decreases immunity protection mechanisms.

AGEs apart from direct damage to biological structures trigger inflammatory response via interaction with RAGE (receptor for AGEs) which contributes to the pathogenesis of several diseases and their complications, including atherosclerosis, diabetes mellitus and chronic renal failure, and finally results in increased cardiovascular morbidity and mortality.

In all animals, including man, the gastrointestinal microflora is the by far the largest "organ" in the body. The microflora conducts a multitude of biochemical reactions, including degradation of a number of dietary substances that are otherwise nondigestible. By having this microflora, the host is relieved of the need to evolve such functions and achieves a degree of metabolic adaptability that can help it deal with changes in diet and nutrient availability. In return the members of this flora are given a "protected", nutrientrich niche in which they can multiply.
To simplify: the question of today is how thermally altered food may act -- directly or indirectly -- upon the microflora and the host.

There is now sufficient scientific evidence to suggest that thermally treated food may dramatically interfere with the microflora and we're starting to find out why.

In the study, one group of mice was fed a diet high in MG over four generations, while the control group was fed a diet without MG. Both diets had normal calories and fat. Over four generations, the mice that ate the MG started to develop early insulin resistance and increased body fat, whereas the control group did not have either of these conditions. The researchers found that MG caused a marked deficiency in protective mechanisms, such as the survival factor SIRT1 that is present in fat and controls inflammation, while enhancing the metabolism of glucose and insulin. The ingestion of MG also adversely affected the activity of an important anti-AGE receptor called AGER1, which protects SIRT1 and fights insulin resistance.

Abdominal fat and inflammation

“This was a prolonged but rewarding study showing that a specific AGE compound abundant in foods, within only a few generations in mouse terms, contributes to the increase in weight gain, insulin resistance, and, diabetes, reproducing the pattern seen increasingly in humans over the last decades ,” said Dr. Vlassara. “These key findings should inform how we understand and prevent the human epidemic of obesity and diabetes.”

The abdominal fat of the MG-fed mice was transformed into a repository of fat cells producing highly inflammatory molecules called cytokines, which impaired glucose metabolism and slowed down fat turnover, and resulted in insulin resistance and diabetes. Mice that were fed the low-in-MG diet displayed high levels of SIRT1, AGER1 and no diabetes.

“The study demonstrates how the prolonged ingestion of seemingly innocuous substances common in human food, such as MG, can reduce defenses and compromise native resistance to metabolic and other diseases,” said Dr. Vlassara. “The mouse findings are also quite exciting because they provide us with new tools, not only to study, but to begin taking measures to prevent diabetes, either by suppressing their formation or by blocking their absorption with our food.”

Recent clinical research by Dr. Vlassara’s team demonstrated that a modest cut in foods high in AGEs improved insulin resistance in adults with type 2 diabetes, without reducing fat or carbohydrate consumption. In other promising studies, the team has used an oral agent that binds AGEs in the intestine, blocking their absorption.

Eliminate foods cooked using dry heat and replace with foods cooked in water or lower heat such as steaming

“For more than 30 years we have been studying the potential of eliminating harmful AGEs from the body, and now from food, as one way to curb the diabetes epidemic,” said Dr. Vlassara. “Thus far, our findings reflect the need for a dramatic departure from standard clinical recommendations, which should now include a reduction in the amount of dry heat and processed foods in the diet.”

The research team recommends that clinical guidelines be revised to eliminate foods cooked using dry heat and replace them with methods that use lower heat or lots of moisture (water) as in stewing, poaching or steaming. Examples from the AGE-less diet include stewed beef, chicken and fish instead of grilled meats. Dr. Vlassara and her colleagues’ new guidelines for an AGE-less diet can be found

April McCarthy is a community journalist playing an active role reporting and analyzing world events to advance our health and eco-friendly initiatives.

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