People who couldn't
stomach a medical study requiring them
to give up chocolate ended up helping
science, anyway.
These chocoholics' blood platelets displayed
a reduced tendency to clot together in
dangerous clumps, researchers found.
Billed as the "first biochemical
analysis" on the subject, the finding
may explain why chocolate can be good
for the heart.
"Chocolate that's flavonoid-rich,
that's dark, that's good quality, that's
not traveling with all of its bad friends
like sugar and fat, probably has some
fairly potent pro-health benefits, although
not as strong as aspirin," said lead
researcher Diane Becker, professor of
medicine at Johns Hopkins University School
of Medicine in Baltimore.
Her belief: "Not all chocolate is
bad."
Becker presented the findings at the
annual meeting of the
American Heart Association, in
Chicago.
Another expert cautioned that chocolate
is just one sweet piece of the dietary
puzzle, however.
The study is "interesting and in
the right direction but the overall diet
is what people ought to be concerned about,"
said Dr. Robert H. Eckel, professor of
medicine at the University of Colorado
School of Medicine in Denver and past
president of the AHA. He was not involved
in this research.
Previous laboratory research had already
shown this effect with large quantities
of dark chocolate, which has high levels
of antioxidants called flavonoids.
"The quantities were far more than
anyone would ever eat and the measurements
were done only two to four hours after
the people consumed it," Becker,
a self-professed chocoholic, explained.
"We didn't know about chocolate consumption
the way people really eat it."
The 139 individuals participating in
this "offshoot" study had already
been disqualified from a larger study
examining the effects of aspirin on blood
platelets. All had a family history of
premature coronary heart disease, putting
them at higher risk for heart disease.
Participants were instructed to follow
a strict exercise regimen and to refrain
from smoking or consuming food or drinks
known to affect the activity of blood
platelets, which are key to clotting.
In addition to coffee, tea and other caffeinated
drinks, this meant chocolate.
The "chocolate offenders" admitted
to eating chocolate on the sly, however.
Rather than just disqualifying them, the
study authors decided to use their cheating
ways for an additional analysis. Becker
and her team tested platelet samples from
the "offenders" and from a control
group to see how long it took for platelets
to clump together.
Chocolate appeared to slow clotting.
On average, platelets in the chocoholics
took 130 seconds to stick together, and
in the control group about 123 seconds.
A test of urine for the waste products
of platelet activity found that chocolate
eaters also had less activity and produced
fewer waste products.
"People who ate chocolate had markedly
lower amounts of urinary excretion of
this byproduct of platelet activity, which
meant that the platelets are not being
activated and not clumping so much in
the body," Becker said. "The
magnitude of the difference is very significant."
"What you eat in everyday life in
relatively small quantities, as long ago
as 12 hours, affects platelet function
-- which is kind of a way to express the
amount of time it takes for blood to clot,"
she continued. "It makes blood less
sticky and less likely to clot and less
likely to be part of a process that could
cause a heart attack."
The bottom line? A little high-quality
chocolate once in a while probably won't
kill you. But follow nutritionists' advice,
too -- don't ingest pounds of the stuff
because the sugar and fat may kill
you.