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Sperm Quality Declines With Age
It isn't only women who face a ticking biological clock
when planning parenthood.
New research has found that as men age, the quality of
their sperm deteriorates, making it more likely they will
have trouble becoming fathers and increasing the possibility
of having a child with dwarfism.
The study, led by Andrew Wyrobek of Lawrence Livermore
National Laboratory and Brenda Eskenazi of the University
of California, Berkeley, School of Public Health, appears
in this week's online edition of the Proceedings of the
National Academy of Sciences.
Women's biological time clock has long been known, with
older women having an increased risk of miscarriage and
of producing children with genetic defects such as Down
Syndrome.
"Our research suggests that men, too, have a biological
time clock only it is different," Eskenazi said in
a statement. "Men seem to have a gradual rather than an
abrupt change in fertility and in the potential ability
to produce viable, healthy offspring."
Both men and women have been postponing parenthood in recent
years. Since 1980, the researchers said, birth rates have
increased 40 percent for men aged 35 to 49, while there
has been a decline in births involving men under 30.
The same team had previously found that as men age their
sperm count declines and their sperm becomes less active.
The new report looked at 97 men aged 22 to 80 and found
increased fragmentation of the DNA in sperm as men age.
"This study shows that men who wait until they're older
to have children are not only risking difficulties conceiving,
they could also be increasing the risk of having children
with genetic problems," said Wyrobek.
Unlike older women, the changes in sperm did not increase
the chance of producing a child with Down Syndrome, they
found. But some older fathers did have an increased risk
of having children with dwarfism and "a small fraction of
men are at increased risks for transmitting multiple genetic
and chromosomal defects."
The study was primarily funded by several grants from the
National Institute of Environmental Health Sciences, part
of the National Institutes of Health,
and the U.S. Environmental Protection
Agency.