Ginger can kill ovarian cancer cells while the
compound that makes peppers hot can shrink pancreatic
tumors, researchers told a conference.
Their studies add to a growing body of evidence
that at least some popular spices might slow or
prevent the growth of cancer.
The study on ginger was done using cells in a lab
dish, which is a long way from finding that it works
in actual cancer patients, but it is the first step
to testing the idea.
Dr. Rebecca Liu, an assistant professor of obstetrics
and gynecology at the University of Michigan Comprehensive
Cancer Center, and colleagues tested ginger powder
dissolved in solution by putting it on ovarian cancer
cell cultures.
It killed the ovarian cancer cells in two different
ways -- through a self-destruction process called
apoptosis and through autophagy in which cells digest
themselves, the researchers told a meeting of the
American Association for Cancer Research.
"Most ovarian cancer patients develop recurrent
disease that eventually becomes resistant to standard
chemotherapy, which is associated with resistance
to apoptosis," Liu said in a statement.
"If ginger can cause autophagic cell death in addition
to apoptosis, it may circumvent resistance to conventional
chemotherapy."
Ovarian cancer kills 16,000 out of the 22,000 U.S.
women who are diagnosed with it every year, according
to the American Cancer Society.
Ginger has been shown to help control inflammation,
which can contribute to the development of ovarian
cancer cells.
"In multiple ovarian cancer cell lines, we found
that ginger-induced cell death at a similar or better
rate than the platinum-based chemotherapy drugs
typically used to treat ovarian cancer," said Dr.
Jennifer Rhode, who helped work on the study.
A second study found that capsaicin, which makes
chili peppers hot, fed to mice caused apoptosis
death in pancreatic cancer cells, said Sanjay Srivastava
of the University of Pittsburgh School of Medicine.
"Capsaicin triggered the cancerous cells to die
off and significantly reduced the size of the tumors,"
he said.
The spicy compound killed pancreatic tumor cells
but did not affect normal, healthy pancreas cells,
researchers told the AACR meeting.
Last year the same team reported similar results
with pancreatic cells in lab dishes. Pancreatic
cancer is highly deadly, killing 31,000 of the 32,000
it will be diagnosed in this year.
Last month researchers in Los Angeles reported
that capsaicin killed prostate tumor cells. Other
studies have shown that turmeric, a yellow spice
used widely in Indian cooking, may help stop the
spread of lung cancer and breast cancer in mice.
Experts point out that many compounds shown to
stop cancer in mice are not nearly as effective
in human cancer patients.