People with high blood levels of the nutrient
beta-carotene may have better lung function as they
age, new research suggests.
What's more, the study found, both beta-carotene
and vitamin E might offer some lung protection to
heavy smokers.
Beta-carotene is an antioxidant compound that gives
foods such as carrots, sweet potatoes and cantaloupe
their orange and yellow coloring; the nutrient is
also found in some greens, like spinach and broccoli.
The new findings suggest that non-smokers and smokers
alike should get plenty of fruits and vegetables
in their diets, according to lead study author Dr.
Armelle Guenegou of the French national health institute
INSERM, in Paris.
Lung function naturally starts a slow decline around
the late 20s, but a healthful diet may help the
lungs stay more youthful, Guenegou stated.
That doesn't mean, however, that smokers can avoid
the consequences of the habit by eating well or
popping vitamins. It's always best to quit smoking,
Guenegou said, given the risks of lung cancer and
cardiovascular disease.
A recent analysis of eight studies, for instance,
concluded that beta-carotene, vitamins A, C and
E, and other nutrients do not cut smokers' risk
of lung cancer.
The new study, published in the medical journal
Thorax, included 1,194 adults ages 20 to 44. At
the outset, participants had their lung function
measured, as well as their blood levels of vitamins
A and E, beta-carotene and a related compound called
alpha-carotene.
Lung function was gauged with an FEV1 score --
the amount of air a person can forcefully exhale
in one second.
Overall, the researchers found, men and women with
higher blood levels of beta-carotene at the study's
start showed a smaller dip FEV1 scores over the
next 8 years.
And among heavy smokers -- those who lit up at
least 20 times a day -- higher levels of both beta-carotene
and vitamin E were related to a slower decline in
lung function.
Smoking generates excess levels of potentially
cell-damaging substances called oxygen free radicals
-- molecules that antioxidants like vitamin E and
beta-carotene are designed to neutralize.
The body converts some of the beta-carotene is
receives into vitamin A, while some is stored in
tissues, including lung tissue. It's possible, Guenegou's
team says, that beta-carotene in the lungs helps
defend against the free-radical attack.
As for why vitamin E appeared protective only in
heavy smokers, the researchers speculate that the
vitamin jumps into a more potent antioxidant mode
only when stress from free radicals is high.
Beta-carotene may also preserve non-smokers' lung
function by battling free radicals, according to
Guenegou. The potentially damaging molecules are
a normal byproduct of metabolism, and they are also
generated by outside sources other than cigarettes
-- air pollution, for example.
The researcher stressed, though, that beta-carotene
is not the sole player in lung or overall health.
So it's important to get a mix of antioxidants and
other nutrients from plant foods, rather than relying
on pills.
SOURCE: Thorax, April 2006.